Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CAD | P27708 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953811 | 0.87 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL2953812 | 0.87 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL2953807 | 0.87 | CYP1A2 (0.44) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL21086900 | 0.85 | CYP1A2 (0.43) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL21086903 | 0.82 | CYP1A2 (0.41) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL19216892 | 0.82 | ITGB1 (0.43) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL11773441 | 0.81 | SMN1; SMN2 (0.46) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL11773446 | 0.81 | SMN1; SMN2 (0.46) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL21086976 | 0.80 | CYP1A2 (0.40) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL13138368 | 0.80 | SMN1; SMN2 (0.43) | CYP1A2CYP2C9CYP2C19HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3503730-B1 | COMPOSITIONS COMPRISING REVERSIBLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF | DICERNA PHARMACEUTICALS INC (US) | 2023-09-27 | — | — | EP | disclosed |
| WO-2018039364-A1 | COMPOSITIONS COMPRISING REVERSIBLY MODIFIED OLIGONUCLEOTIDES AND USES THEREOF | DICERNA PHARMACEUTICALS, INC. (US) | 2018-03-01 | — | — | WO | disclosed |