Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | TNKS | O95271 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | ETV6 | P41212 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873090 | 0.87 | PLK4 (0.47) | PLK4FLT3AURKATNKSNTRK1 | |
| SCHEMBL29602504 | 0.85 | LRRK2 (0.68) | NTRK1FGFR1FLT1KDRETV6 | |
| SCHEMBL5872977 | 0.84 | TNKS (0.46) | PLK4FLT3AURKATNKSNTRK1 | |
| SCHEMBL19928117 | 0.84 | PLK4 (0.58) | PLK4FLT3AURKATNKSNTRK1 | |
| SCHEMBL18930828 | 0.81 | FGFR1 (0.63) | MAP4K1FGFR1FLT1LRRK2 | |
| SCHEMBL16025465 | 0.81 | LRRK2 (0.74) | PLK4FLT3MAP4K1FGFR1FLT1 | |
| SCHEMBL6521241 | 0.80 | LRRK2 (0.53) | PLK4FLT3AURKANTRK1MAP4K1 | |
| SCHEMBL585871 | 0.80 | PLK4 (0.54) | PLK4FLT3AURKATNKSMAP4K1 | |
| SCHEMBL21179906 | 0.77 | PLK4 (0.59) | PLK4FLT3AURKATNKSNTRK1 | |
| SCHEMBL5872877 | 0.77 | LRRK2 (0.46) | NTRK1KDRETV6LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9907800-B2 | Kinase inhibitors and method of treating cancer | UNIVERSITY HEALTH NETWORK (CA) | 2018-03-06 | — | — | US | disclosed |