Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ETV6 | P41212 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873090 | 0.90 | PLK4 (0.47) | TLR9TLR8TLR7ACVR1NTRK1 | |
| SCHEMBL5873162 | 0.89 | NTRK1 (0.55) | TLR9TLR8TLR7ACVR1NTRK1 | |
| SCHEMBL6506307 | 0.88 | LRRK2 (0.53) | LRRK2NTRK1MAPK1KDRETV6 | |
| SCHEMBL5872891 | 0.86 | FLT3 (0.46) | LRRK2TLR8TLR7ACVR1NTRK1 | |
| SCHEMBL5873038 | 0.85 | NTRK1 (0.40) | LRRK2ACVR1NTRK1MAPK1 | |
| SCHEMBL5872887 | 0.83 | ACVR1 (0.44) | ACVR1NTRK1 | |
| SCHEMBL5873134 | 0.83 | PIM1 (0.42) | ACVR1NTRK1 | |
| SCHEMBL5873069 | 0.80 | KDR (0.43) | ACVR1NTRK1KDRETV6 | |
| SCHEMBL5873036 | 0.78 | IDO1 (0.43) | LRRK2 | |
| SCHEMBL5872977 | 0.78 | TNKS (0.46) | LRRK2TLR9TLR8TLR7ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | LRRK2 2922/4885TLR9 956/4885TLR8 1034/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | LRRK2 2922/4885TLR9 956/4885TLR8 1034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.