Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15833604 | 0.75 | MAPT (0.41) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL19836258 | 0.74 | KDM4E (0.38) | MAPTKDM4ENSD2ALDH1A1 | |
| SCHEMBL30426567 | 0.74 | MAT2A (0.40) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL15819411 | 0.73 | ADORA2A (0.46) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL19421522 | 0.71 | MAPT (0.38) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL31600322 | 0.71 | CYP1A2 (0.40) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL25786732 | 0.71 | MAPT (0.38) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL30876453 | 0.69 | CCR1 (0.45) | MAPTKDM4ENSD2ALDH1A1ADORA1 | |
| SCHEMBL31721638 | 0.68 | MAT2A (0.38) | MAPTKDM4ENSD2ALDH1A1KCNH2 | |
| SCHEMBL21604597 | 0.68 | ADORA2A (0.37) | MAPTKDM4ENSD2ALDH1A1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908887-B2 | PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2018-03-06 | — | — | US | disclosed |