Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19075307 | 0.89 | JAK2 (0.32) | JAK2 | |
| SCHEMBL23220228 | 0.87 | JAK2 (0.36) | JAK2 | |
| SCHEMBL3006804 | 0.81 | JAK2 (0.32) | JAK2JAK1 | |
| SCHEMBL3006796 | 0.81 | JAK2 (0.32) | JAK2JAK1 | |
| SCHEMBL3006800 | 0.81 | JAK2 (0.32) | JAK2JAK1 | |
| SCHEMBL19928587 | 0.80 | JAK2 (0.31) | JAK2JAK1 | |
| SCHEMBL31720850 | 0.80 | JAK1 (0.42) | JAK2JAK1 | |
| SCHEMBL31330413 | 0.80 | JAK1 (0.42) | JAK2JAK1 | |
| SCHEMBL2994164 | 0.80 | JAK1 (0.42) | JAK2JAK1 | |
| SCHEMBL2999949 | 0.80 | JAK1 (0.42) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908888-B2 | Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines | INCYTE CORPORATION (US) | 2018-03-06 | — | — | US | disclosed |