Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928590 | 0.89 | JAK2 (0.35) | JAK2 | |
| SCHEMBL23220225 | 0.80 | SIGMAR1 (0.41) | JAK2 | |
| SCHEMBL19928587 | 0.79 | JAK2 (0.31) | JAK2 | |
| SCHEMBL21083833 | 0.78 | KDM5B (0.39) | — | |
| SCHEMBL3006796 | 0.78 | JAK2 (0.32) | JAK2 | |
| SCHEMBL3005736 | 0.78 | JAK1 (0.41) | JAK2 | |
| SCHEMBL31330334 | 0.78 | JAK1 (0.41) | JAK2 | |
| SCHEMBL3006804 | 0.78 | JAK2 (0.32) | JAK2 | |
| SCHEMBL3006800 | 0.78 | JAK2 (0.32) | JAK2 | |
| SCHEMBL3005734 | 0.78 | JAK1 (0.41) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398774-B1 | PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS | INCYTE HOLDINGS CORP (US) | 2017-07-05 | — | — | EP | disclosed |