Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.42 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | GMNN | O75496 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928630 | 0.87 | FABP3 (0.41) | SMPD1SMN1; SMN2MEN1KMT2AS1PR1 | |
| SCHEMBL12313943 | 0.87 | FABP3 (0.41) | SMPD1SMN1; SMN2MEN1KMT2AS1PR1 | |
| SCHEMBL31467436 | 0.83 | SMPD1 (0.74) | SMPD1MEN1KMT2AS1PR1PLA2G1B | |
| SCHEMBL19928625 | 0.79 | MEN1 (0.68) | SMPD1SMN1; SMN2MEN1KMT2AS1PR1 | |
| SCHEMBL19821629 | 0.76 | PLA2G1B (0.60) | SMN1; SMN2PLA2G1BPLA2G2AADRA1DPTAFR | |
| SCHEMBL195823 | 0.73 | SMPD1 (0.75) | SMPD1MEN1KMT2AS1PR1PLA2G1B | |
| SCHEMBL14889266 | 0.73 | SMPD1 (0.75) | SMPD1MEN1KMT2AS1PR1PLA2G1B | |
| SCHEMBL30884227 | 0.73 | SMPD1 (0.75) | SMPD1MEN1KMT2AS1PR1PLA2G1B | |
| SCHEMBL19759836 | 0.73 | SMPD1 (0.75) | SMPD1MEN1KMT2AS1PR1PLA2G1B | |
| SCHEMBL29693688 | 0.73 | SMPD1 (0.75) | SMPD1MEN1KMT2AS1PR1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11841362-B2 | Method for the diagnosis of Niemann-Pick disease | CENTOGENE GMBH (DE) | 2023-12-12 | — | — | US | disclosed |
| US-20220187283-A1 | Method for the Diagnosis of Niemann-Pick Disease | CENTOGENE GMBH (DE) | 2022-06-16 | — | — | US | disclosed |
| US-11231412-B2 | Method for the diagnosis of Niemann-Pick disease | CENTOGENE GMBH (DE) | 2022-01-25 | — | — | US | disclosed |
| US-20200072819-A1 | Method for the Diagnosis of Niemann-Pick Disease | CENTOGENE GMBH (DE) | 2020-03-05 | — | — | US | disclosed |
| US-10422789-B2 | Method for the diagnosis of Niemann-Pick disease | CENTOGENE AG (DE) | 2019-09-24 | — | — | US | disclosed |
| US-10302664-B2 | Method for the diagnosis of Niemann-Pick disease | CENTOGENE AG (DE) | 2019-05-28 | — | — | US | disclosed |
| US-20180088107-A1 | Method for the Diagnosis of Niemann-Pick Disease | CENTOGENE GMBH (DE) | 2018-03-29 | — | — | US | disclosed |
| US-9910033-B2 | Method for the diagnosis of Niemann-Pick disease | CENTOGENE AG (DE) | 2018-03-06 | — | — | US | disclosed |