Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CHKA | P35790 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178285 | 0.92 | KDM4E (0.42) | SIGMAR1KDM4EGLATSHRL3MBTL1 | |
| SCHEMBL24713588 | 0.92 | KDM4E (0.42) | SIGMAR1KDM4EGLATSHRL3MBTL1 | |
| SCHEMBL22550677 | 0.92 | KDM4E (0.42) | SIGMAR1KDM4EGLATSHRL3MBTL1 | |
| SCHEMBL27346812 | 0.85 | SIGMAR1 (0.41) | SIGMAR1KDM4ECHKACA2NCF1 | |
| SCHEMBL15223351 | 0.83 | KMT2A (0.44) | SIGMAR1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL11929538 | 0.83 | KMT2A (0.44) | SIGMAR1KDM4EL3MBTL1MAPTALDH1A1 | |
| SCHEMBL11570592 | 0.82 | — | — | |
| SCHEMBL20355886 | 0.82 | SIGMAR1 (0.39) | SIGMAR1KDM4ECHKACA2NCF1 | |
| SCHEMBL10147160 | 0.81 | PIK3CD (0.45) | SIGMAR1KDM4ECHKACA2NCF1 | |
| SCHEMBL22605258 | 0.81 | MEN1 (0.48) | SIGMAR1KDM4ETSHRL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908872-B2 | Methods to treat lymphoplasmacytic lymphoma | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-06 | — | — | US | disclosed |