Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.78 |
| ▸ | CDK4 | P11802 | 16/20 | 0.72 |
| ▸ | CDK1 | P06493 | 4/20 | 0.72 |
| ▸ | CCND3 | P30281 | 3/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.72 |
| ▸ | FECH | P22830 | 1/20 | 0.72 |
| ▸ | CCND1 | P24385 | 1/20 | 0.72 |
| ▸ | CDK9 | P50750 | 1/20 | 0.72 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.72 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.72 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.72 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.72 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.72 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.72 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.72 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29639522 | 0.98 | CDK2 (0.80) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL2298262 | 0.98 | CDK2 (0.80) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL26641432 | 0.95 | CDK2 (0.75) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL15153216 | 0.94 | CDK2 (0.74) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL28619136 | 0.94 | CDK4 (0.74) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL15153191 | 0.94 | CDK2 (0.72) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL31727518 | 0.93 | CDK2 (0.72) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL28620311 | 0.92 | CDK4 (0.76) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL30643564 | 0.92 | CDK4 (0.80) | CDK2CDK4CDK1CCND3GAK | |
| SCHEMBL31728206 | 0.91 | CDK4 (0.77) | CDK2CDK4CDK1CCND3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043428-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS LTD. (GB) | 2024-02-08 | — | — | US | disclosed |
| US-20210253578-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS LTD. (GB) | 2021-08-19 | — | — | US | disclosed |
| US-20180155351-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2018-06-07 | — | — | US | disclosed |
| US-20170183352-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2017-06-29 | — | — | US | disclosed |
| US-9416136-B2 | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG (CH) | 2016-08-16 | — | — | US | disclosed |
| US-8962630-B2 | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG (CH) | 2015-02-24 | — | — | US | disclosed |
| EP-2331547-B1 | PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS | NOVARTIS AG (CH) | 2014-07-30 | — | — | EP | disclosed |
| US-20140135312-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS LTD. (GB) | 2014-05-15 | — | — | US | disclosed |
| US-20130184285-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS (GB) | 2013-07-18 | — | — | US | disclosed |
| US-8415355-B2 | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG (CH) | 2013-04-09 | — | — | US | disclosed |
| US-20110152244-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2011-06-23 | — | — | US | disclosed |
| EP-2331547-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS | Novartis AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| US-20100105653-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG | 2010-04-29 | — | — | US | disclosed |
| WO-2010020675-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS | NOVARTIS AG (CH) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152244-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20130184285-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20170183352-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20240043428-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20180155351-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20210253578-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20100105653-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
| US-20140135312-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK4 5/4885CDK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.