SCHEMBL2298262

SCHEMBL2298262

CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)nc2n1C1CCCC1

nearest known ligand 0.80

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 4/20 0.80
CDK4 P11802 16/20 0.74
CDK1 P06493 4/20 0.74
CCND3 P30281 3/20 0.74
GAK O14976 1/20 0.74
CCNT1 O60563 1/20 0.74
CCNA2 P20248 1/20 0.74
FECH P22830 1/20 0.74
CCND1 P24385 1/20 0.74
CDK9 P50750 1/20 0.74
CDK6 Q00534 1/20 0.74
CDK16 Q00536 1/20 0.74
MAP3K1 Q13233 1/20 0.74
CAMK2G Q13555 1/20 0.74
CAMK2D Q13557 1/20 0.74
Q6ZSR9 Q6ZSR9 1/20 0.74
PRKD2 Q9BZL6 1/20 0.74
SIK2 Q9H0K1 1/20 0.74
HDAC1 Q13547 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29639522 1.00 CDK2 (0.80) CDK2CDK4CDK1CCND3GAK
SCHEMBL1992896 0.98 CDK2 (0.78) CDK2CDK4CDK1CCND3GAK
SCHEMBL26641432 0.96 CDK2 (0.75) CDK2CDK4CDK1CCND3GAK
SCHEMBL15153216 0.96 CDK2 (0.74) CDK2CDK4CDK1CCND3GAK
SCHEMBL28619136 0.95 CDK4 (0.74) CDK2CDK4CDK1CCND3GAK
SCHEMBL15153191 0.95 CDK2 (0.72) CDK2CDK4CDK1CCND3GAK
SCHEMBL31727518 0.94 CDK2 (0.72) CDK2CDK4CDK1CCND3GAK
SCHEMBL28620311 0.94 CDK4 (0.76) CDK2CDK4CDK1CCND3GAK
SCHEMBL30643564 0.93 CDK4 (0.80) CDK2CDK4CDK1CCND3GAK
SCHEMBL31728206 0.92 CDK4 (0.77) CDK2CDK4CDK1CCND3GAK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210122754-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF RIBOCICLIB SUCCINATE AND ITS NOVEL CRYSTALLINE FORMS THEREOF NATCO PHARMA LTD (IN) 2021-04-29 US claimed
WO-2019142206-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF RIBOCICLIB SUCCINATE AND ITS NOVEL CRYSTALLINE FORMS THEREOF NATCO PHARMA LIMITED (IN) 2019-07-25 WO claimed
EP-4313987-B1 PROCESS FOR THE PREPARATION OF RIBOCICLIB AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA D D NOVO MESTO (SI) 2026-01-14 EP disclosed
EP-4626890-A1 RIBOCICLIB SALTS AND FORMULATIONS THEREOF KRKA, d.d., Novo mesto (SI) 2025-10-08 EP disclosed
US-12421227-B2 Ribociclib salts and solid state forms thereof ASSIA CHEMICAL INDUSTRIES LTD. (IL) 2025-09-23 US disclosed
WO-2024115680-A1 RIBOCICLIB SALTS AND FORMULATIONS THEREOF KRKA, D.D., NOVO MESTO (SI) 2024-06-06 WO disclosed
EP-4327880-A2 SOLID STATE FORM OF RIBOCICLIB SUCCINATE Assia Chemical Industries Ltd (IL) 2024-02-28 EP disclosed
EP-4313987-A2 PROCESS FOR THE PREPARATION OF RIBOCICLIB AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, d.d., Novo mesto (SI) 2024-02-07 EP disclosed
EP-3672968-B1 SOLID STATE FORM OF RIBOCICLIB SUCCINATE ASSIA CHEM IND LTD (IL) 2023-11-01 EP disclosed
CN-111386272-B Improved preparation method of Riboxib and salt thereof 费森尤斯卡比肿瘤学有限公司 2023-01-06 CN disclosed
US-11440912-B2 Process for the preparation of ribociclib and its salts FRESENIUS KABI ONCOLOGY LTD (IN) 2022-09-13 US disclosed
US-8957074-B2 Pyrrolopyrimidine compounds as inhibitors of CDK4/6 NOVARTIS AG (CH) 2015-02-17 US disclosed
US-20130217698-A1 SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF ASTEX THERAPEUTICS LTD (GB) 2013-08-22 US disclosed
US-20130217698-A1 SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF ASTEX THERAPEUTICS LTD (GB) 2013-08-22 US disclosed
US-20130150342-A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 NOVARTIS AG (CH) 2013-06-13 US disclosed
EP-2536730-A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 Novartis AG (CH) 2012-12-26 EP disclosed
WO-2012064805-A1 SALT(S) OF 7-CYCLOPENTYL-2 -(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF NOVARTIS AG (CH) 2012-05-18 WO disclosed
US-20120115878-A1 SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF CALIENNI JOHN VINCENT (US) 2012-05-10 US disclosed
US-20120115878-A1 SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF CALIENNI JOHN VINCENT (US) 2012-05-10 US disclosed
WO-2011101409-A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 NOVARTIS AG (CH) 2011-08-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11440912-B2 Process for the preparation of ribociclib and its salts SUCLG2, IDH1, RRM2B CDK2 138/4885CDK4 75/4885CDK1 837/4885
US-20130150342-A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 CDK4, CDK6, CCNT1 CDK2 9/4885CDK4 1/4885CDK1 11/4885
US-20130217698-A1 SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF PKD2, SLC6A7, DHPS CDK2 2620/4885CDK4 2373/4885CDK1 4131/4885
US-12421227-B2 Ribociclib salts and solid state forms thereof RTCB, KRAS, RRM2B CDK2 25/4885CDK4 11/4885CDK1 231/4885
US-20120115878-A1 SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF PKD2, SLC6A7, DHPS CDK2 2620/4885CDK4 2373/4885CDK1 4131/4885
US-20210122754-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF RIBOCICLIB SUCCINATE AND ITS NOVEL CRYSTALLINE FORMS THEREOF RRM2B, CPS1, RRBP1 CDK2 34/4885CDK4 111/4885CDK1 254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.