Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.72 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.72 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.72 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.72 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.72 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.72 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.72 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.72 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.47 |
| ▸ | TUBB | P07437 | 2/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251712 | 0.86 | HDAC6 (0.54) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1999049 | 0.86 | HDAC6 (0.83) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1608403 | 0.86 | HDAC8 (0.71) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1609261 | 0.86 | HDAC8 (0.74) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL30014115 | 0.84 | HDAC6 (1.00) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1608763 | 0.84 | HDAC6 (1.00) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1609205 | 0.84 | HDAC8 (0.71) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1609252 | 0.82 | HDAC6 (0.65) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1609201 | 0.81 | HDAC6 (0.74) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL1608298 | 0.81 | HDAC8 (0.78) | HDAC8HDAC6HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371281-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS LLC (US) | 2016-06-21 | — | — | US | claimed |
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2015-10-22 | — | — | US | claimed |
| US-20150038542-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 AND TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS LLC | 2015-02-05 | — | — | US | claimed |
| US-20130078215-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2013-03-28 | — | — | US | claimed |
| US-20110150825-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2011-06-23 | — | — | US | claimed |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-12-06 | — | — | US | claimed |
| US-9371281-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2015-10-22 | — | — | US | disclosed |
| US-20150038542-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 AND TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS LLC | 2015-02-05 | — | — | US | disclosed |
| US-8900565-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130156727-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20130078215-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
| US-8338416-B2 | Indole derivatives as inhibitors of histone deacetylase | PHARMACYLICS, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20110150825-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-7820711-B2 | Uses of selective inhibitors of HDAC8 for treatment of T-cell proliferative disorders | PHARMACYCLICS INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20090203010-A1 | MSMB-gene based diagnosis, staging and prognosis of prostate cancer | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2009-08-13 | — | — | US | disclosed |
| WO-2009089598-A2 | MSMB-GENE METHYLATION BASED DIAGNOSIS, STAGING AND PROGNOSIS OF PROSTATE CANCER | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2009-07-23 | — | — | WO | disclosed |
| US-20080112889-A1 | Uses of Selective Inhibitors of HDAC8 for Treatment of T-Cell Proliferative Disorders | PHARMACYCLICS, INC. (US) | 2008-05-15 | — | — | US | disclosed |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299119-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | HDAC8 1/4885HDAC6 10/4885HDAC1 2/4885 |
| US-20080112889-A1 | Uses of Selective Inhibitors of HDAC8 for Treatment of T-Cell Proliferative Disorders | HDAC8, HDAC5, HDAC7 | HDAC8 1/4885HDAC6 12/4885HDAC1 4/4885 |
| US-20110150825-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | HDAC8, HDAC2, HDAC7 | HDAC8 1/4885HDAC6 9/4885HDAC1 5/4885 |
| US-20070281934-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | HDAC8 1/4885HDAC6 10/4885HDAC1 2/4885 |
| US-20130078215-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | HDAC8, HDAC2, HDAC7 | HDAC8 1/4885HDAC6 9/4885HDAC1 5/4885 |
| US-20090203010-A1 | MSMB-gene based diagnosis, staging and prognosis of prostate cancer | MAT2B, DNMT3B, SHBG | HDAC8 2668/4885HDAC6 4661/4885HDAC1 3460/4885 |
| US-20150038542-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 AND TREATMENT OF INFLAMMATORY CONDITIONS | HDAC8, HDAC2, HDAC7 | HDAC8 1/4885HDAC6 9/4885HDAC1 5/4885 |
| US-20130156727-A1 | INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC2 | HDAC8 1/4885HDAC6 10/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.