SCHEMBL1993019

SCHEMBL1993019

CN(c1ccnc(-c2cnc3ccc(F)cn23)n1)C1CCCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EIF2AK4 Q9P2K8 18/20 0.50
PRMT5 O14744 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1993022 1.00 EIF2AK4 (0.50) EIF2AK4PRMT5
SCHEMBL1997166 0.90 EIF2AK4 (0.48) EIF2AK4
SCHEMBL1997165 0.90 EIF2AK4 (0.48) EIF2AK4
SCHEMBL1996002 0.89 EIF2AK4 (0.47) EIF2AK4
SCHEMBL2038354 0.89 EIF2AK4 (0.48) EIF2AK4
SCHEMBL1995220 0.89 EIF2AK4 (0.47) EIF2AK4PRMT5
SCHEMBL1995218 0.89 EIF2AK4 (0.47) EIF2AK4PRMT5
SCHEMBL12643871 0.88 EIF2AK4 (0.46) EIF2AK4PRMT5
SCHEMBL1994173 0.86 EIF2AK4 (0.48) EIF2AK4
SCHEMBL12644112 0.86 EIF2AK4 (0.46) EIF2AK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516436-A1 IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS Almirall S.A. (ES) 2012-10-31 EP disclosed
WO-2011076419-A1 IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS ALMIRALL, S.A. (ES) 2011-06-30 WO disclosed
EP-2338888-A1 Imidazopyridine derivatives as JAK inhibitors Almirall, S.A. (ES) 2011-06-29 EP disclosed