Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 4/20 | 0.34 |
| ▸ | RARB | P10826 | 4/20 | 0.34 |
| ▸ | RARG | P13631 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16650065 | 0.67 | BRD4 (1.00) | BRD4BRD9 | |
| SCHEMBL19930836 | 0.66 | BRD4 (0.53) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL21915977 | 0.66 | BRD4 (0.70) | BRD4BRD9 | |
| SCHEMBL19930732 | 0.66 | BRD4 (0.70) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL25043209 | 0.62 | BRD4 (0.48) | BRD4 | |
| SCHEMBL19930749 | 0.61 | BRD4 (0.58) | BRD4TTK | |
| SCHEMBL19930745 | 0.59 | AURKA (0.50) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL6915411 | 0.58 | BRD4 (0.49) | BRD4GLACREBBPCYP1A2CYP2C19 | |
| SCHEMBL10426066 | 0.58 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2D6MAOACYP2C19 | |
| SCHEMBL19857658 | 0.57 | BRD4 (0.60) | BRD4AURKATTKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640241-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |