Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 18/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19930749 | 0.74 | BRD4 (0.58) | BRD4TTK | |
| SCHEMBL19930835 | 0.73 | BRD4 (0.71) | BRD4 | |
| SCHEMBL16651168 | 0.70 | BRD4 (1.00) | BRD4MAPTKMT2A | |
| SCHEMBL21915803 | 0.69 | BRD4 (0.68) | BRD4 | |
| SCHEMBL19930732 | 0.66 | BRD4 (0.70) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL19930645 | 0.66 | BRD4 (0.52) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL16650500 | 0.62 | BRD4 (1.00) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL18508160 | 0.62 | BRD4 (0.50) | BRD4 | |
| SCHEMBL21998643 | 0.62 | BRD4 (0.68) | BRD4AURKATTKAURKBINCENP | |
| SCHEMBL8522276 | 0.60 | LMNA (0.51) | KDM4EMEN1ALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |