Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 4/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19931105 | 0.83 | BRD4 (0.35) | P2RX3BRD4EP300 | |
| SCHEMBL25043121 | 0.80 | BRD4 (0.34) | P2RX3BRD4EP300 | |
| SCHEMBL19930852 | 0.74 | BRD4 (0.32) | BRD4EP300 | |
| SCHEMBL19930893 | 0.74 | BRD4 (0.35) | BRD4EP300PDE4B | |
| SCHEMBL19931045 | 0.73 | PDE4A (0.32) | P2RX3BRD4EP300PDE4APDE4B | |
| SCHEMBL19930750 | 0.73 | BRD4 (0.36) | C5AR1BRD4EP300 | |
| SCHEMBL19930964 | 0.73 | BRD4 (0.33) | BRD4EP300PDE4B | |
| SCHEMBL19931222 | 0.73 | BRD4 (0.33) | BRD4EP300PDE4APDE4BPDE4C | |
| SCHEMBL19930995 | 0.72 | BRD4 (0.34) | BRD4EP300PDE4APDE4BPDE4C | |
| SCHEMBL19930937 | 0.71 | BRD4 (0.36) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3640241-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |