SCHEMBL19931069

SCHEMBL19931069

CCSNc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3c2CCC3)c1

nearest known ligand 0.60

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 0.60
BRD2 P25440 1/20 0.49
ADORA2B P29275 1/20 0.49
TSPO P30536 1/20 0.49
EP300 Q09472 1/20 0.49
BRD3 Q15059 1/20 0.49
BRDT Q58F21 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19931124 0.90 BRD4 (0.58) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL25043109 0.89 BRD4 (0.77) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL16650620 0.85 BRD4 (0.80) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL16651239 0.83 BRD4 (0.66) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL19931186 0.83 BRD4 (0.60) BRD4
SCHEMBL19931488 0.82 BRD4 (0.55) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL20155130 0.81 BRD4 (0.51) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL19930759 0.80 BRD4 (0.53) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL23556122 0.80 BRD4 (0.75) BRD4BRD2ADORA2BTSPOEP300
SCHEMBL20154943 0.80 BRD4 (0.65) BRD4BRD2ADORA2BTSPOEP300

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4134364-A2 BROMODOMAIN INHIBITORS Celgene Quanticel Research, Inc. (US) 2023-02-15 EP disclosed
EP-3640241-A1 BROMODOMAIN INHIBITORS Celgene Quanticel Research, Inc. (US) 2020-04-22 EP disclosed
EP-3290407-A1 BROMODOMAIN INHIBITORS Celgene Quanticel Research, Inc (US) 2018-03-07 EP disclosed