Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.51 |
| ▸ | ALB | P02768 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | POLA1 | P09884 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | POLG | P54098 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912374 | 1.00 | PDE3A (0.62) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL13713969 | 1.00 | PDE3A (0.62) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL6153492 | 0.89 | PDE3A (0.61) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL13487257 | 0.88 | PDE3A (0.60) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL15189232 | 0.88 | PDE3A (0.60) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL13813007 | 0.88 | PDE3A (0.60) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL14180581 | 0.88 | PDE3A (0.60) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL18270531 | 0.86 | PDE3A (0.49) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL24735360 | 0.85 | PDE3A (0.50) | PDE3APDE4DSLC29A1LMNACACNA1F | |
| SCHEMBL26247475 | 0.85 | PDE3A (0.50) | PDE3APDE4DSLC29A1LMNACACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3545968-A1 | MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE 3 KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-2858666-B1 | MUTANT SELECTIVITY AND COMBINATIONS OF A PHOSPHOINOSITIDE 3 KINASE INHIBITOR COMPOUND AND CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |
| EP-2968382-B1 | SUBSTITUTED GEMCITABINE BICYCLIC AMIDE ANALOGS AND TREATMENT METHODS USING SAME | NUCORION PHARMACEUTICALS INC (US) | 2018-03-07 | — | — | EP | disclosed |