Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12065342 | 0.84 | ACKR3 (0.51) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL24862784 | 0.83 | ACKR3 (0.48) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL13181804 | 0.81 | ACKR3 (0.53) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL2025339 | 0.80 | ACKR3 (0.53) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL2025336 | 0.80 | ACKR3 (0.53) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL23747111 | 0.80 | ACKR3 (0.57) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL18768306 | 0.79 | ACKR3 (0.53) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL4013908 | 0.78 | ACKR3 (0.60) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL4014855 | 0.78 | ACKR3 (0.60) | ACKR3KDM1AMEN1ALDH1A1MAPT | |
| SCHEMBL17207589 | 0.78 | ACKR3 (0.57) | ACKR3KDM1AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018041947-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF AUTOIMMUNE OR INFLAMMATORY DISEASES OR CANCERS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-08 | — | — | WO | disclosed |