Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.75 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.75 |
| ▸ | ABL1 | P00519 | 3/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | MTOR | P42345 | 3/20 | 0.59 |
| ▸ | PRKDC | P78527 | 3/20 | 0.59 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11902020 | 0.88 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL21107958 | 0.87 | CSNK1E (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGCSNK1E | |
| SCHEMBL19935751 | 0.87 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL7909457 | 0.85 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL20885087 | 0.85 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL17925342 | 0.82 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL16386557 | 0.82 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL16386554 | 0.82 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL16347659 | 0.82 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 | |
| SCHEMBL19935807 | 0.82 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3016955-B1 | PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS | RHIZEN PHARMACEUTICALS S A (CH) | 2018-03-07 | — | — | EP | disclosed |