Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936593 | 0.78 | MAPK1 (0.36) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819570 | 0.71 | MAPK1 (0.39) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819784 | 0.71 | MAPK1 (0.41) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819776 | 0.70 | CACNA1H (0.43) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819582 | 0.70 | TP53 (0.40) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819771 | 0.70 | NPC1 (0.40) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936538 | 0.70 | MAPK1 (0.37) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936465 | 0.69 | MAPK1 (0.35) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936555 | 0.69 | MAPK1 (0.35) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819569 | 0.69 | MAPT (0.42) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |