Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19936538 | 0.93 | MAPK1 (0.37) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936555 | 0.87 | MAPK1 (0.35) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936464 | 0.78 | SMN1; SMN2 (0.32) | SMN1; SMN2 | |
| SCHEMBL19936596 | 0.78 | MAPK1 (0.33) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL19936587 | 0.77 | SMN1; SMN2 (0.34) | POLBCYP1A2MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL14819784 | 0.72 | MAPK1 (0.41) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819570 | 0.72 | MAPK1 (0.39) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819771 | 0.71 | NPC1 (0.40) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819776 | 0.71 | CACNA1H (0.43) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL14819582 | 0.71 | TP53 (0.40) | MAPK1PIK3CAMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594555-B1 | HETEROCYCLIC COMPOUND, AND p27 KIP1 DEGRADATION INHIBITOR | ASKA PHARM CO LTD (JP) | 2018-03-07 | — | — | EP | disclosed |