Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.41 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.41 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15890110 | 0.87 | MAPT (0.48) | MAPTKDM4ETHRBHTTNPC1 | |
| SCHEMBL15890081 | 0.87 | MAPT (0.48) | MAPTKDM4ETHRBHTTNPC1 | |
| SCHEMBL18685698 | 0.84 | KDM4E (0.52) | MAPTKDM4ETHRBHTTGPR119 | |
| SCHEMBL4235039 | 0.83 | MAPT (0.51) | MAPTKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL19937657 | 0.82 | MAP3K12 (0.55) | MAP3K12 | |
| SCHEMBL5453963 | 0.81 | KDM4E (0.49) | MAPTKDM4ETHRBHTTALDH1A1 | |
| SCHEMBL18403235 | 0.80 | KDM4E (0.48) | MAPTKDM4ETHRBHTTGPR119 | |
| SCHEMBL15890111 | 0.79 | GPR119 (0.45) | MAPTKDM4ETHRBHTTNPC1 | |
| SCHEMBL15283360 | 0.78 | KDM4E (0.51) | MAPTKDM4ETHRBHTTNPC1 | |
| SCHEMBL16827791 | 0.77 | MEN1 (0.60) | MAPTTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |