Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 18/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937768 | 0.76 | MAP3K12 (0.46) | MAP3K12 | |
| SCHEMBL19937617 | 0.75 | MAP3K12 (0.50) | MAP3K12 | |
| SCHEMBL19937593 | 0.74 | MAP3K12 (0.51) | MAP3K12 | |
| SCHEMBL19938766 | 0.73 | MAP3K12 (0.47) | MAP3K12 | |
| SCHEMBL19937816 | 0.73 | MAP3K12 (0.52) | MAP3K12PIK3CA | |
| SCHEMBL19937595 | 0.70 | MAP3K12 (0.53) | MAP3K12 | |
| SCHEMBL17387976 | 0.70 | MAP3K12 (0.65) | MAP3K12 | |
| SCHEMBL19921671 | 0.70 | MAP3K12 (0.65) | MAP3K12 | |
| SCHEMBL15889973 | 0.70 | MAP3K12 (0.65) | MAP3K12 | |
| SCHEMBL19937776 | 0.69 | MAP3K12 (0.44) | MAP3K12PIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |