Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 18/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19937608 | 0.81 | MAP3K12 (0.52) | MAP3K12TNFPIK3CA | |
| SCHEMBL19937665 | 0.79 | MAP3K12 (0.52) | MAP3K12TNF | |
| SCHEMBL19937631 | 0.77 | MAP3K12 (0.54) | MAP3K12TNF | |
| SCHEMBL19937793 | 0.74 | MAP3K12 (0.52) | MAP3K12TNFPIK3CA | |
| SCHEMBL19937616 | 0.73 | MAP3K12 (0.57) | MAP3K12TNFPIK3CA | |
| SCHEMBL19937784 | 0.73 | MAP3K12 (0.39) | MAP3K12PIK3CA | |
| SCHEMBL19937787 | 0.72 | MAP3K12 (0.54) | MAP3K12TNF | |
| SCHEMBL19937642 | 0.71 | MAP3K12 (0.55) | MAP3K12TNF | |
| SCHEMBL19937751 | 0.71 | MAP3K12 (0.53) | MAP3K12TNF | |
| SCHEMBL18403198 | 0.69 | MAP3K12 (1.00) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2945938-B1 | 3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2018-03-07 | — | — | EP | disclosed |