Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.46 |
| ▸ | GRM5 | P41594 | 7/20 | 0.46 |
| ▸ | LIPC | P11150 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 2/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718282 | 0.90 | NAMPT (0.56) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL30798377 | 0.90 | NAMPT (0.56) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL3033965 | 0.88 | NAMPT (0.54) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL30736648 | 0.88 | NAMPT (0.54) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL15380388 | 0.87 | NAMPT (0.53) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL30798334 | 0.87 | NAMPT (0.53) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL29152538 | 0.87 | NAMPT (0.53) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL31612866 | 0.87 | NAMPT (0.53) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL16992228 | 0.87 | QDPR (0.54) | NAMPTPDK4CDK7CDK13CDK12 | |
| SCHEMBL15157008 | 0.87 | NAMPT (0.56) | NAMPTPDK4CDK7CDK13CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018041248-A1 | BCL-2 SELECTIVE INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2018-03-08 | — | — | WO | disclosed |