Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482925 | 0.79 | CNR2 (0.48) | RORCCA12CA1CA2CA9 | |
| SCHEMBL4057443 | 0.79 | KDM4E (0.48) | KDM4ETSHRHSD17B10CHEK1CCNT1 | |
| SCHEMBL1700273 | 0.77 | BRD4 (0.43) | KDM4ETSHRHSD17B10PTGS2CHEK1 | |
| SCHEMBL1700000 | 0.77 | BRD4 (0.43) | KDM4ETSHRHSD17B10PTGS2CHEK1 | |
| SCHEMBL31344660 | 0.77 | BRD4 (0.43) | KDM4ETSHRHSD17B10PTGS2CHEK1 | |
| SCHEMBL3385858 | 0.76 | SMN1; SMN2 (0.51) | KDM4ETSHRHSD17B10 | |
| SCHEMBL13432211 | 0.76 | KDM4E (0.48) | KDM4ETSHRHSD17B10CHEK1CCNT1 | |
| SCHEMBL1700918 | 0.76 | BRD4 (0.43) | — | |
| SCHEMBL19940506 | 0.76 | KDM4E (0.46) | KDM4ETSHRHSD17B10CHEK1CCNT1 | |
| Sulfanilamide SCHEMBL1955933 | 0.75 | CA2 (0.47) | TSHRRORCCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641897-B | Bcl-2 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-109293656-A | Bcl-2 selective depressant and its preparation and use | 北京赛林泰医药技术有限公司 | 2019-02-01 | — | — | CN | disclosed |
| WO-2018041248-A1 | BCL-2 SELECTIVE INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2018-03-08 | — | — | WO | disclosed |