Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19924971 | 0.84 | CDK2 (0.47) | MAPTPOLBPKMMEN1KMT2A | |
| SCHEMBL27325893 | 0.84 | MAPT (0.61) | MAPTPOLBPKMMEN1KMT2A | |
| SCHEMBL4198828 | 0.81 | MAPT (0.80) | MAPTPOLBPKMMEN1KMT2A | |
| SCHEMBL2468178 | 0.79 | MAPT (0.55) | MAPTPOLBPKMMEN1KMT2A | |
| SCHEMBL17241872 | 0.78 | NPC1 (0.58) | MAPTCNR1MEN1KMT2ALMNA | |
| SCHEMBL108393 | 0.77 | KMT2A (0.65) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL14063302 | 0.77 | MAPT (0.54) | MAPTPOLBPKMMEN1KMT2A | |
| SCHEMBL29390080 | 0.77 | KMT2A (0.65) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL19941889 | 0.77 | POLB (0.52) | MAPTPOLBPKMMEN1KMT2A | |
| SCHEMBL27291436 | 0.76 | MAPT (0.61) | MAPTPOLBPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018042342-A1 | 1,2,3-BENZOTRIAZOLE DERIVATIVES AS ROR GAMMA T MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2018-03-08 | — | — | WO | disclosed |