Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989544 | 0.89 | CHRM2 (0.39) | KDM4ECHRM2CHRM1CHRM3MAPT | |
| SCHEMBL2036928 | 0.80 | CHRM2 (0.43) | CHRM2CHRM1CHRM3ALDH1A1 | |
| SCHEMBL2035758 | 0.77 | KDM4E (0.45) | KDM4EKDM4CALDH1A1MEN1HTT | |
| SCHEMBL2037374 | 0.77 | CHRM2 (0.40) | CHRM2CHRM1CHRM3ALDH1A1 | |
| SCHEMBL3433946 | 0.74 | SLC1A2 (0.40) | KDM4EKDM4CALDH1A1MEN1KMT2A | |
| SCHEMBL15140580 | 0.72 | CHRM2 (0.43) | CHRM2CHRM1CHRM3 | |
| SCHEMBL15140579 | 0.72 | CHRM2 (0.43) | CHRM2CHRM1CHRM3 | |
| SCHEMBL15140581 | 0.72 | CHRM2 (0.43) | CHRM2CHRM1CHRM3 | |
| Trifluoroacetic Acid SCHEMBL350087 | 0.72 | HRH4 (0.43) | CHRM2CHRM1CHRM3 | |
| SCHEMBL15579312 | 0.72 | MAPT (0.37) | MAPTPKMKDM2BSLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2512246-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075560-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |