Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038839 | 0.84 | GPR88 (0.42) | KDM4EGPR88SCN3AMEN1HTT | |
| SCHEMBL2035875 | 0.78 | KDM4E (0.40) | KDM4EGPR88KDM4CMEN1HTT | |
| SCHEMBL1994249 | 0.77 | KDM4E (0.42) | KDM4EGPR88KDM4CMEN1HTT | |
| SCHEMBL2039087 | 0.77 | KDM4E (0.48) | KDM4EGPR88KDM4CMEN1HTT | |
| SCHEMBL2046508 | 0.72 | KDM4E (0.37) | KDM4EKDM4CMEN1HTTKMT2A | |
| SCHEMBL2037647 | 0.72 | KDM4E (0.47) | KDM4EKDM4CMEN1HTTKMT2A | |
| SCHEMBL2014210 | 0.72 | KDM4E (0.43) | KDM4EKDM4CMEN1HTTKMT2A | |
| SCHEMBL3433946 | 0.72 | SLC1A2 (0.40) | KDM4EKDM4CMEN1KMT2AALDH1A1 | |
| SCHEMBL20656877 | 0.71 | — | — | |
| SCHEMBL9278938 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |