⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797097 | 0.75 | — | — | |
| SCHEMBL1456892 | 0.74 | HCAR2 (0.41) | — | |
| SCHEMBL5070318 | 0.70 | KDR (0.41) | — | |
| SCHEMBL390310 | 0.70 | — | — | |
| SCHEMBL8644938 | 0.70 | — | — | |
| SCHEMBL392004 | 0.70 | — | — | |
| SCHEMBL1310784 | 0.70 | — | — | |
| SCHEMBL11747703 | 0.70 | — | — | |
| SCHEMBL11707071 | 0.68 | — | — | |
| SCHEMBL4780826 | 0.67 | USP2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648250-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | MERCK SHARP & DOHME LLC (US) | 2023-05-16 | — | — | US | claimed |
| CN-111533697-B | 4-aminopyridazinone compound and preparation method thereof | 成都大学 | 2023-03-31 | — | — | CN | claimed |
| CN-111533697-A | 4-aminopyridazinone compound and preparation method thereof | 成都大学 | 2020-08-14 | — | — | CN | claimed |
| US-8946225-B2 | Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2015-02-03 | — | — | US | claimed |
| US-20120178678-A1 | DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2012-07-12 | — | — | US | claimed |
| EP-2462121-A1 | DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS | Pierre Fabre Médicament (FR) | 2012-06-13 | — | — | EP | claimed |
| WO-2011082941-A1 | BENZYL-SUBSTITUTED THIADIAZOLYL OXYPHENYL AMIDINIUM SALTS AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2011-07-14 | — | — | WO | claimed |
| US-7459453-B2 | Pyridazin-3(2H)-one derivatives as PDE4 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-12-02 | — | — | US | claimed |
| US-20060052379-A1 | Pyridazin-3(2h)-one derivatives as pde4 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-03-09 | — | — | US | claimed |
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | claimed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | claimed |
| EP-0352638-B1 | 5-Amino-6-pyridazinon-derivatives, process for their preparation and herbicidal agent containing them | BASF AG (DE) | 1995-02-22 | — | — | EP | claimed |
| US-5123952-A | Postemergence herbicides | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-23 | — | — | US | claimed |
| JP-8034734-A | — | — | None | — | — | JP | disclosed |
| JP-63156778-A | — | — | None | — | — | JP | disclosed |
| CN-118993944-A | Guanidine-substituted aromatic ester derivative, preparation method and medical application thereof | 中国医学科学院药物研究所 | 2024-11-22 | — | — | CN | disclosed |
| EP-0352638-A2 | 5-Amino-6-pyridazinon-derivatives, process for their preparation and herbicidal agent containing them | BASF Aktiengesellschaft (DE) | 1990-01-31 | — | — | EP | disclosed |
| JP-S63156778-A | AMINOPYRIDAZINONE DERIVATIVE, PRODUCTION THEREOF, INSECTICIDE AND ACARICIDE CONTAINING SAID DERIVATIVE AND ACTIVE INGREDIENT | UBE IND LTD | 1988-06-29 | — | — | JP | disclosed |
| US-4297493-A | Manufacture of 4-amino-5-chloro-1-phenylpyridaz-6-one using aqueous phenol-4-sulfonic acid | BASF AKTIENGESELLSCHAFT (DE) | 1981-10-27 | — | — | US | disclosed |
| JP-H00834734-A | — | — | 0001-01-01 | — | — | JP | disclosed |