Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 15/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19946123 | 0.85 | AAK1 (0.84) | AAK1DYRK1A | |
| SCHEMBL19946141 | 0.85 | AAK1 (0.61) | AAK1 | |
| SCHEMBL16972637 | 0.84 | AAK1 (0.47) | AAK1DYRK1AMAOA | |
| SCHEMBL21018876 | 0.83 | AAK1 (0.66) | AAK1DYRK1AMAOABCHEACHE | |
| SCHEMBL19946030 | 0.82 | AAK1 (0.62) | AAK1 | |
| SCHEMBL15562280 | 0.82 | AAK1 (0.49) | AAK1DYRK1A | |
| SCHEMBL15562155 | 0.81 | AAK1 (0.52) | AAK1DYRK1A | |
| SCHEMBL21019088 | 0.81 | AAK1 (0.63) | AAK1DYRK1AMAOABCHEACHE | |
| SCHEMBL19946110 | 0.81 | AAK1 (0.62) | AAK1DYRK1AMAOA | |
| SCHEMBL21018881 | 0.79 | AAK1 (0.69) | AAK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292124-A2 | FUSED PYRIDINES AS ADAPTOR ASSOCIATED KINASE 1 (AAK1) INHIBITORS | Bristol-Myers Squibb Company (US) | 2018-03-14 | — | — | EP | disclosed |