Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19946326 | 0.84 | MAPK8 (0.49) | PPARGPPARAMAPK8SMN1; SMN2NLRP3 | |
| SCHEMBL1948655 | 0.82 | CA12 (0.50) | PPARGPPARASMN1; SMN2IDO1 | |
| SCHEMBL1948560 | 0.81 | HDAC1 (0.41) | PPARGPPARAHDAC1MAPTSMN1; SMN2 | |
| SCHEMBL27739636 | 0.79 | PPARG (0.46) | PPARGPPARAMAPK8HDAC1HDAC8 | |
| SCHEMBL30678949 | 0.78 | HDAC1 (0.41) | PPARGPPARAMAPK8HDAC1HDAC8 | |
| SCHEMBL13595526 | 0.78 | PPARG (0.48) | PPARGPPARALMNAMAPT | |
| SCHEMBL841124 | 0.77 | CYP4F2 (0.58) | MAPK8HDAC1HDAC8MAPK10PIK3CA | |
| SCHEMBL4574985 | 0.77 | LSS (0.52) | PPARGPPARAHDAC1HDAC8EPHX2 | |
| SCHEMBL4655026 | 0.76 | CA12 (0.44) | PPARGPPARAMAPTSMN1; SMN2 | |
| SCHEMBL7739224 | 0.76 | NR1H2 (0.40) | PPARGPPARANR1H2NR1H3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848618-B1 | NITROGENATED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2018-03-14 | — | — | EP | disclosed |