Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315721 | 0.82 | CA12 (0.51) | PPARGPPARA | |
| SCHEMBL19946331 | 0.79 | PPARG (0.48) | PPARGPPARAHDAC1HDAC8NLRP3 | |
| SCHEMBL4574985 | 0.78 | LSS (0.52) | PPARGPPARAHDAC1HDAC8EPHX2 | |
| SCHEMBL7978684 | 0.75 | GAA (0.48) | PPARGPPARAHDAC1HDAC8MAOB | |
| SCHEMBL8112750 | 0.74 | PPARG (0.60) | PPARGPPARAHDAC8 | |
| SCHEMBL15261546 | 0.73 | PPARG (0.46) | PPARGPPARAMAOBMAPTRXRA | |
| SCHEMBL265118 | 0.72 | PIK3CA (0.53) | HDAC1HDAC8NLRP3MAOBHRH3 | |
| SCHEMBL17687214 | 0.72 | PHGDH (0.46) | PPARGPPARA | |
| SCHEMBL1853151 | 0.72 | CYP17A1 (0.54) | PPARGPPARAHDAC1MAPTEPHX2 | |
| SCHEMBL1138925 | 0.72 | EPHX2 (0.59) | MAPTRXFP1EPHX2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421265-A | Thiazole compounds as protein kinase b (pkb) inhibitors | AMGEN INC (US) | 2009-04-29 | — | — | CN | disclosed |