Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | GLI1 | P08151 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Proline SCHEMBL15210884 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL20897288 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| D-Proline SCHEMBL5665276 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL3442547 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL3428913 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL499448 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL499449 | 1.00 | NOS2 (0.42) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL28093320 | 0.96 | NOS2 (0.40) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL28101824 | 0.96 | NOS2 (0.40) | NOS2NOS3NOS1MEN1BLM | |
| Proline SCHEMBL1828861 | 0.95 | NOS2 (0.39) | NOS2NOS3NOS1MEN1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071369-A1 | GLUTAMATE OXALOACETATE TRANSAMINASE 1 (GOT1), PREPARATIONS AND METHODS OF GENERATING SAME AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2018-03-15 | — | — | US | disclosed |