Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 4/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19948214 | 1.00 | C5AR1 (0.45) | C5AR1CFTRPARP1TNKS2PARP2 | |
| SCHEMBL19959331 | 0.89 | C5AR1 (0.43) | C5AR1CHRM4KDM4EALDH1A1GAA | |
| SCHEMBL30189197 | 0.89 | C5AR1 (0.43) | C5AR1CHRM4KDM4EALDH1A1GAA | |
| SCHEMBL30188729 | 0.89 | C5AR1 (0.43) | C5AR1CHRM4KDM4EALDH1A1GAA | |
| SCHEMBL19959345 | 0.89 | C5AR1 (0.43) | C5AR1CHRM4KDM4EALDH1A1GAA | |
| SCHEMBL19948656 | 0.87 | C5AR1 (0.45) | C5AR1CFTRPARP1TNKS2PARP2 | |
| SCHEMBL15105402 | 0.86 | C5AR1 (0.52) | C5AR1CFTRALDH1A1GAAKMT2A | |
| SCHEMBL15105401 | 0.86 | C5AR1 (0.52) | C5AR1CFTRALDH1A1GAAKMT2A | |
| SCHEMBL23075026 | 0.84 | GPR119 (0.42) | C5AR1PARP1CHRM4MAPT | |
| SCHEMBL21315097 | 0.83 | C5AR1 (0.48) | C5AR1CFTRPARP1TNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101553-A1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2024-03-28 | — | — | US | disclosed |
| US-20230373999-A1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-11-23 | — | — | US | disclosed |
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| US-20200262837-A1 | KRAS G12C INHIBITORS | ARRAY BIOPHARMA INC. | 2020-08-20 | — | — | US | disclosed |
| US-10689377-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2020-06-23 | — | — | US | disclosed |
| US-10633381-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190144444-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2019-05-16 | — | — | US | disclosed |
| US-10125134-B2 | KRas G12C inhibitors | Mirati Therapeutics, Inc. (US) | 2018-11-13 | — | — | US | disclosed |
| US-20180072723-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144444-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-10633381-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-20200262837-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-10125134-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-10689377-B2 | KRas G12C inhibitors | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-20240101553-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-20180072723-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
| US-20230373999-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | C5AR1 4146/4885CFTR 95/4885PARP1 1128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.