Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 7/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.38 |
| ▸ | JAK3 | P52333 | 8/20 | 0.38 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997370 | 0.85 | EIF2AK4 (0.42) | ADORA2AIRAK4IRAK1EIF2AK4FLT3 | |
| SCHEMBL1994795 | 0.85 | EIF2AK4 (0.42) | ADORA2AIRAK4IRAK1EIF2AK4FLT3 | |
| SCHEMBL2037145 | 0.78 | ADORA2A (0.44) | ADORA2AIRAK4IRAK1EIF2AK4FLT3 | |
| SCHEMBL13505191 | 0.77 | IRAK4 (0.50) | IRAK4IRAK1EIF2AK4FLT3JAK2 | |
| SCHEMBL1993495 | 0.76 | IRAK4 (0.47) | ADORA2AIRAK4IRAK1EIF2AK4FLT3 | |
| SCHEMBL12643901 | 0.76 | IRAK4 (0.47) | ADORA2AIRAK4IRAK1EIF2AK4FLT3 | |
| Methyl Alcohol SCHEMBL15193449 | 0.76 | IRAK4 (0.46) | ADORA2AIRAK4IRAK1EIF2AK4FLT3 | |
| SCHEMBL1997054 | 0.75 | IRAK4 (0.46) | IRAK4IRAK1EIF2AK4FLT3JAK2 | |
| SCHEMBL15198123 | 0.75 | IRAK4 (0.46) | IRAK4IRAK1EIF2AK4FLT3JAK2 | |
| SCHEMBL1994606 | 0.74 | IRAK4 (0.49) | IRAK4IRAK1EIF2AK4FLT3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |