Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 9/20 | 0.41 |
| ▸ | JAK3 | P52333 | 9/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 5/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997864 | 0.94 | ADORA2A (0.45) | ADORA2AJAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1991798 | 0.90 | ADORA2A (0.44) | ADORA2AJAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1993894 | 0.83 | IRAK4 (0.46) | JAK2JAK3JAK1EIF2AK4IRAK4 | |
| SCHEMBL12616583 | 0.81 | EIF2AK4 (0.40) | EIF2AK4IRAK4KIT | |
| SCHEMBL1998010 | 0.80 | IRAK4 (0.49) | JAK2JAK3JAK1EIF2AK4IRAK4 | |
| SCHEMBL1994795 | 0.79 | EIF2AK4 (0.42) | ADORA2AJAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1997370 | 0.79 | EIF2AK4 (0.42) | ADORA2AJAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1994913 | 0.78 | ADORA2A (0.41) | ADORA2AJAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL12643880 | 0.78 | EIF2AK4 (0.47) | EIF2AK4 | |
| SCHEMBL13505191 | 0.77 | IRAK4 (0.50) | JAK2JAK3JAK1EIF2AK4IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |