Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mannitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mannitol SCHEMBL31441251 | 1.00 | LMNA (0.69) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Galactitol SCHEMBL31441250 | 1.00 | LMNA (0.69) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Adonitol SCHEMBL28446207 | 0.94 | PDE4A (0.59) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Mannitol SCHEMBL30410531 | 0.90 | LMNA (0.73) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Mannitol SCHEMBL27844169 | 0.90 | LMNA (0.73) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Sorbitol SCHEMBL31013480 | 0.90 | LMNA (0.73) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Gluconic Acid SCHEMBL1001814 | 0.87 | PDE4A (0.91) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Gluconic Acid SCHEMBL27590197 | 0.87 | PDE4A (0.91) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| E968 SCHEMBL28441780 | 0.87 | PDE4A (0.50) | LMNAL3MBTL1PDE4ATDP1USP2 | |
| Mannitol SCHEMBL3951741 | 0.87 | LMNA (0.92) | LMNAL3MBTL1PDE4ATDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106631779-B | Polyol esters and their use in processing halogenated vinyl polymers | 济南金昌树新材料科技有限公司 | 2020-07-14 | — | — | CN | disclosed |
| EP-3509605-A1 | LIPSOMAL ANTICANCER COMPOSITIONS | Irisys, Inc. (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018048752-A1 | LIPSOMAL ANTICANCER COMPOSITIONS | IRISYS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |