Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.53 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.45 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28903756 | 0.85 | MELK (0.64) | MELKMAP4K1PRKD1JAK2 | |
| SCHEMBL19951623 | 0.82 | MAP4K1 (0.45) | TNKSMELKMAP4K1TDO2ACVR1B | |
| SCHEMBL28903809 | 0.78 | MELK (0.70) | MELKMAP4K1PRKD1JAK2 | |
| SCHEMBL28903771 | 0.77 | MELK (0.71) | MELKMAP4K1PRKD1JAK2 | |
| SCHEMBL28903755 | 0.74 | TNKS (0.52) | TNKSMELKMAP4K1FYNTDO2 | |
| SCHEMBL28748471 | 0.74 | TNKS (0.40) | TNKSMELKMAP4K1PRKD1DYRK1A | |
| SCHEMBL28903817 | 0.74 | MELK (0.63) | MELKMAP4K1PRKD1 | |
| SCHEMBL19951736 | 0.73 | MAP4K1 (0.54) | MELKMAP4K1 | |
| SCHEMBL19949883 | 0.73 | MAP4K1 (0.46) | TNKSMAP4K1TDO2TGFBR1 | |
| SCHEMBL28642628 | 0.73 | MAP4K1 (0.44) | TNKSMAP4K1FYNTDO2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049214-A9 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-10-18 | — | — | WO | disclosed |
| WO-2018049214-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |