Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.45 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.45 |
| ▸ | KIT | P10721 | 4/20 | 0.45 |
| ▸ | TNKS | O95271 | 3/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951649 | 0.82 | TNKS (0.53) | MAP4K1TNKSTDO2MELKACVR1B | |
| SCHEMBL19951676 | 0.78 | MAP4K1 (0.45) | MAP4K1FLT3NTRK1KIT | |
| SCHEMBL19949869 | 0.77 | MAP4K1 (0.45) | MAP4K1FLT3NTRK1KITTDO2 | |
| SCHEMBL19951650 | 0.76 | ALDH1A1 (0.52) | MAP4K1FLT3NTRK1KITALK | |
| SCHEMBL19950196 | 0.73 | MAP4K1 (0.69) | MAP4K1FLT3NTRK1KITTDO2 | |
| SCHEMBL30069599 | 0.73 | MAP4K1 (0.69) | MAP4K1FLT3NTRK1KITTDO2 | |
| SCHEMBL28905423 | 0.70 | MAP4K1 (0.54) | MAP4K1FLT3NTRK1KITDYRK1A | |
| SCHEMBL30032035 | 0.70 | MAP4K1 (0.54) | MAP4K1FLT3NTRK1KITDYRK1A | |
| SCHEMBL20791805 | 0.70 | NTRK1 (0.44) | MAP4K1FLT3NTRK1KITRET | |
| SCHEMBL28903755 | 0.69 | TNKS (0.52) | MAP4K1TNKSTDO2MELKMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049214-A9 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-10-18 | — | — | WO | disclosed |
| WO-2018049214-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |