Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951681 | 0.89 | MAP4K1 (0.39) | MAP4K1NTRK1KITFLT3SYK | |
| SCHEMBL19950436 | 0.88 | MAP4K1 (0.40) | MAP4K1NTRK1KITFLT3CREBBP | |
| SCHEMBL19950315 | 0.86 | ALDH1A1 (0.43) | MAP4K1NTRK1KITFLT3CREBBP | |
| SCHEMBL19950443 | 0.83 | MAP4K1 (0.43) | MAP4K1NTRK1KITFLT3AXL | |
| SCHEMBL19950429 | 0.82 | ALDH1A1 (0.41) | MAP4K1NTRK1KITFLT3MAPK1 | |
| SCHEMBL19950488 | 0.82 | MAP4K1 (0.44) | MAP4K1NTRK1KITFLT3MAPK1 | |
| SCHEMBL19950231 | 0.81 | MAP4K1 (0.47) | MAP4K1NTRK1KITFLT3CREBBP | |
| SCHEMBL19950226 | 0.81 | MAP4K1 (0.47) | MAP4K1NTRK1KITFLT3CREBBP | |
| SCHEMBL19950599 | 0.80 | MAP4K1 (0.46) | MAP4K1NTRK1KITFLT3TYRO3 | |
| SCHEMBL19950023 | 0.80 | MAP4K1 (0.40) | MAP4K1NTRK1KITFLT3CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510032-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | Incyte Corporation (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049200-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |