Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19948748 | 0.86 | RIPK1 (0.39) | RIPK1KDM4ESMN1; SMN2TRPV1OPRL1 | |
| SCHEMBL19948761 | 0.83 | PDE10A (0.41) | KDM4ECYP1A2PDE10AMEN1KMT2A | |
| SCHEMBL18710387 | 0.80 | HTR1D (0.31) | — | |
| SCHEMBL16290325 | 0.79 | TNKS (0.31) | — | |
| SCHEMBL16290324 | 0.77 | CA1 (0.47) | OPRL1MEN1KMT2ACA12CA1 | |
| SCHEMBL18710440 | 0.76 | HTR2A (0.31) | — | |
| SCHEMBL16290385 | 0.74 | HTR2A (0.34) | — | |
| SCHEMBL18710390 | 0.73 | SCN9A (0.35) | OPRL1BDKRB1 | |
| SCHEMBL16290658 | 0.72 | CA12 (0.36) | BDKRB1CA12CA1CA2CA7 | |
| SCHEMBL17040899 | 0.70 | BDKRB1 (0.44) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049152-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |