Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 20/20 | 0.81 |
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.81 |
| ▸ | TLR9 | Q9NR96 | 13/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29584759 | 0.89 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL19951812 | 0.89 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL29585479 | 0.87 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL19952377 | 0.87 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL24017888 | 0.87 | TLR8 (0.82) | TLR8TLR7TLR9 | |
| SCHEMBL19952384 | 0.86 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL19952059 | 0.86 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL21967947 | 0.86 | TLR8 (0.86) | TLR8TLR7TLR9 | |
| SCHEMBL19952470 | 0.86 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL29585621 | 0.86 | TLR8 (1.00) | TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3510024-B1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-17 | — | — | EP | claimed |
| US-10660877-B2 | Pyridyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-05-26 | — | — | US | claimed |
| US-20190262311-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-08-29 | — | — | US | claimed |
| EP-3510024-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2019-07-17 | — | — | EP | claimed |
| WO-2018049089-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-15 | — | — | WO | claimed |
| EP-3510024-B1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-17 | — | — | EP | disclosed |
| EP-3510024-B1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-17 | — | — | EP | disclosed |
| US-10660877-B2 | Pyridyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190262311-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-08-29 | — | — | US | disclosed |
| EP-3510024-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049089-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190262311-A1 | PYRIDYL SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR9, TLR1 | TLR8 4/4885TLR7 1/4885TLR9 2/4885 |
| US-10660877-B2 | Pyridyl substituted indole compounds | TLR7, TLR9, TLR1 | TLR8 4/4885TLR7 1/4885TLR9 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.