Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LDLR | P01130 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676747 | 0.87 | CYP11B1 (0.50) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 | |
| SCHEMBL19953122 | 0.83 | HSP90AA1 (0.46) | CYP11B1CYP11B2HSP90AA1HSP90AB1LMNA | |
| SCHEMBL11394015 | 0.83 | CRBN (0.48) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 | |
| SCHEMBL12685600 | 0.82 | IDO1 (0.49) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 | |
| SCHEMBL27989267 | 0.80 | CYP11B1 (0.48) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL19953112 | 0.80 | CRBN (0.53) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 | |
| SCHEMBL27836638 | 0.79 | CRBN (0.45) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 | |
| SCHEMBL11384012 | 0.79 | CYP11B1 (0.59) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 | |
| SCHEMBL6291198 | 0.77 | PTGS2 (0.60) | IDO1 | |
| SCHEMBL27989478 | 0.77 | CYP11B1 (0.49) | CYP11B1CYP11B2CRBNHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048969-A1 | MULTI-TARGETED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-03-15 | — | — | WO | disclosed |
| CN-1178938-C | 1,2-annelated quinoline derivatives | ղɭҩҵ����˾ | 2004-12-08 | — | — | CN | disclosed |
| CN-1331693-A | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-16 | — | — | CN | disclosed |