Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19967313 | 0.78 | POLB (0.36) | POLBMEN1NPC1KMT2AGAA | |
| SCHEMBL1075463 | 0.78 | POLB (0.41) | POLBKDM4EGRM5 | |
| SCHEMBL1076433 | 0.75 | KCNH2 (0.35) | POLBNPC1MAPTRAB9AKCNH2 | |
| SCHEMBL19953096 | 0.73 | PIK3CA (0.40) | MEN1NPC1KMT2AMAPTRAB9A | |
| SCHEMBL1073301 | 0.72 | POLB (0.41) | POLBNPC1RAB9AKDM4EGRM5 | |
| SCHEMBL1073760 | 0.72 | POLB (0.36) | POLBKDM4EPTGS2 | |
| SCHEMBL1074860 | 0.71 | POLB (0.36) | POLBKMT2AGAAKDM4EKCNH2 | |
| SCHEMBL19953168 | 0.70 | SMN1; SMN2 (0.36) | POLBPTGS2 | |
| SCHEMBL1076197 | 0.70 | POLB (0.38) | POLBKDM4EGRM5 | |
| SCHEMBL1075285 | 0.70 | POLB (0.35) | POLBMEN1NPC1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048969-A1 | MULTI-TARGETED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-03-15 | — | — | WO | disclosed |