Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19955759 | 0.89 | NR1I2 (0.38) | NR1I2 | |
| SCHEMBL19955506 | 0.89 | NR1I2 (0.40) | NR1I2KDM4E | |
| SCHEMBL19955544 | 0.87 | NR1I2 (0.37) | NR1I2PDE4A | |
| SCHEMBL19955627 | 0.86 | NR1I2 (0.35) | NR1I2PDE4A | |
| SCHEMBL18928152 | 0.86 | NR1I2 (0.38) | NR1I2 | |
| SCHEMBL19955781 | 0.86 | NR1I2 (0.41) | NR1I2 | |
| SCHEMBL19955597 | 0.86 | NR1I2 (0.36) | NR1I2 | |
| SCHEMBL19955807 | 0.85 | NR1I2 (0.36) | NR1I2PDE4A | |
| SCHEMBL19955601 | 0.85 | NR1I2 (0.37) | NR1I2 | |
| SCHEMBL19955737 | 0.85 | NR1I2 (0.40) | NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166925-B1 | ISOINDOLINE DERIVATIVES FOR USE IN THE TREATMENT OF A VIRAL INFECTION | VIIV HEALTHCARE UK LTD (GB) | 2018-03-14 | — | — | EP | disclosed |