⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6729455 | 0.81 | — | — | |
| SCHEMBL6725219 | 0.79 | — | — | |
| SCHEMBL10504338 | 0.77 | TRPA1 (0.41) | — | |
| SCHEMBL10503017 | 0.77 | TRPA1 (0.41) | — | |
| SCHEMBL6718207 | 0.77 | TRPA1 (0.41) | — | |
| SCHEMBL6721776 | 0.77 | — | — | |
| SCHEMBL14645381 | 0.75 | — | — | |
| SCHEMBL7708782 | 0.72 | — | — | |
| SCHEMBL1014295 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL4186876 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253362-A1 | ARYL ISOXAZOLINE COMPOUND AND USE THEREOF | 沈阳中化农药化工研发有限公司 | 2022-12-08 | — | — | WO | claimed |
| CN-115433177-A | Aryl isoxazoline compound and application thereof | 沈阳中化农药化工研发有限公司 | 2022-12-06 | — | — | CN | claimed |
| US-8026231-B2 | Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof | CNRS (FR) | 2011-09-27 | — | — | US | claimed |
| US-20070032476-A1 | Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof | CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2007-02-08 | — | — | US | claimed |
| US-7078402-B2 | Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2006-07-18 | — | — | US | claimed |
| EP-1296946-B1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | GALDERMA RES & DEV (FR) | 2004-04-21 | — | — | EP | claimed |
| US-20030181443-A1 | Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof | ADVANCED BIODESIGN (FR) | 2003-09-25 | — | — | US | claimed |
| EP-0947503-B1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | claimed |
| US-6117902-A | 6,8-dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical and pharmaceutical compositions intended for the treatment of cancerous tumors | GALDERMAN RESEARCH & DEVELOPMENT, S.N.C. SOPHIA ABTIPOLIS (FR) | 2000-09-12 | — | — | US | claimed |
| EP-0947503-A1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | claimed |
| EP-0623343-A1 | Ketamine analogues for the treatment of thrombocytopenia | GENENTECH, INC. (US) | 1994-11-09 | — | — | EP | claimed |
| US-5250732-A | Influence replication, differentiation or maturation of platelet progenitor cells | GENENTECH, INC. (US) | 1993-10-05 | — | — | US | claimed |
| EP-0217804-B1 | ANALOGS OF SUBSTANCES P | ENICHEM S.p.A. (IT) | 1991-10-02 | — | — | EP | claimed |
| EP-0173933-B1 | 1,6-NAPHTHYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENT CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-11-29 | — | — | EP | claimed |
| EP-0217804-A1 | ANALOGS OF SUBSTANCES P. | ENICHEM SPA (IT) | 1987-04-15 | — | — | EP | claimed |
| US-4638046-A | Retro-inverso C-terminal hexapeptide analogues of substance P | ENI-ENTE NAZIONALE IDROCARBURI (IT) | 1987-01-20 | — | — | US | claimed |
| WO-1986003495-A2 | DERIVATIVES OF SUBSTANCES P AND OF FRAGMENTS THEREOF | ENICHEM S.P.A. (IT) | 1986-06-19 | — | — | WO | claimed |
| EP-0082568-B1 | RETRO-INVERSO ANALOGUES OF C-TERMINAL PENTA AND HEXAPEPTIDES OF SUBSTANCE P. | ANIC S.p.A. (IT) | 1984-11-21 | — | — | EP | claimed |
| US-4439360-A | Retro-inverso analogues of C-terminal penta and hexapeptides of Substance P | ANIC S.P.A. (IT) | 1984-03-27 | — | — | US | claimed |
| EP-0082568-A2 | Retro-inverso analogues of C-terminal penta and hexapeptides of substance P. | ANIC S.p.A. (IT) | 1983-06-29 | — | — | EP | claimed |