Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | LIPE | Q05469 | 6/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8989513 | 0.79 | KMT2A (0.56) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL14523045 | 0.79 | KMT2A (0.51) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL706406 | 0.79 | KMT2A (0.51) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL30980818 | 0.79 | TSHR (0.63) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL706407 | 0.79 | TSHR (0.63) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL4121890 | 0.78 | HPGD (0.46) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL6270313 | 0.78 | MRGPRX4 (0.46) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL11351938 | 0.78 | MAPT (0.69) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL2001524 | 0.77 | HPGD (0.48) | KMT2ATSHRSMN1; SMN2HPGDTHRB | |
| SCHEMBL6267415 | 0.77 | MRGPRX4 (0.45) | KMT2ATSHRSMN1; SMN2HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097078-B1 | PYRIDINES AND PYRIMIDINES AND USE THEREOF | PURDUE PHARMA LP (US) | 2022-05-25 | — | — | EP | disclosed |
| EP-3293184-B1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2020-12-16 | — | — | EP | disclosed |
| EP-3083606-B1 | PYRIMIDINES AND USE THEREOF | PURDUE PHARMA LP (US) | 2020-10-28 | — | — | EP | disclosed |
| EP-3666274-A1 | CARBOXAMIDE DERIVATIVES AND USE THEREOF | Purdue Pharma LP (US) | 2020-06-17 | — | — | EP | disclosed |
| EP-3087059-B1 | INDAZOLES AND USE THEREOF | PURDUE PHARMA LP (US) | 2020-04-29 | — | — | EP | disclosed |
| EP-3039019-B1 | AZASPIRO[4.5]DECANE DERIVATIVES AND USE THEREOF | PURDUE PHARMA LP (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3105217-B1 | ISOQUINOLINE DERIVATIVES AND USE THEREOF | PURDUE PHARMA LP (US) | 2019-05-29 | — | — | EP | disclosed |
| EP-2964639-B1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-3293184-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma L.P. (US) | 2018-03-14 | — | — | EP | disclosed |