SCHEMBL14523045

SCHEMBL14523045

FC(F)(F)c1ccc(OI)nc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.51
TSHR P16473 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HPGD P15428 1/20 0.49
THRB P10828 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
MAPT P10636 2/20 0.46
NPSR1 Q6W5P4 1/20 0.46
MAPK1 P28482 1/20 0.46
POLB P06746 1/20 0.45
LMNA P02545 1/20 0.45
RAB9A P51151 1/20 0.42
MRGPRX4 Q96LA9 1/20 0.42
LIPE Q05469 5/20 0.41
BCHE P06276 1/20 0.40
GABRA5 P31644 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8989513 0.79 KMT2A (0.56) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL30980818 0.79 TSHR (0.63) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL706406 0.79 KMT2A (0.51) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL706407 0.79 TSHR (0.63) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL19956152 0.79 KMT2A (0.51) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL11351938 0.78 MAPT (0.69) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL20381743 0.77 HPGD (0.48) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL5080403 0.77 MRGPRX4 (0.48) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL1995774 0.76 HPGD (0.50) KMT2ATSHRSMN1; SMN2HPGDTHRB
SCHEMBL2737128 0.76 TSHR (0.51) KMT2ATSHRSMN1; SMN2HPGDTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10702507-B2 Endoparasite control agent THE UNIVERSITY OF TOKYO (JP) 2020-07-07 US disclosed
US-20190046511-A1 ENDOPARASITE CONTROL AGENT THE UNIVERSITY OF TOKYO (JP) 2019-02-14 US disclosed
WO-2007072201-A2 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2007-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190046511-A1 ENDOPARASITE CONTROL AGENT NAAA, CTRL, ENPP1 KMT2A 272/4885TSHR 4137/4885SMN1; SMN2 4395/4885
US-10702507-B2 Endoparasite control agent NAAA, CTRL, ENPP1 KMT2A 272/4885TSHR 4137/4885SMN1; SMN2 4395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.