Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 2/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13190252 | 0.79 | DGAT1 (0.68) | MKNK2DGAT1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL19956781 | 0.79 | DGAT1 (0.68) | MKNK2DGAT1ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL13190441 | 0.76 | DGAT1 (0.65) | DGAT1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL13190315 | 0.76 | PI4KA (0.62) | DGAT1KMT2ASMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL3697841 | 0.76 | MKNK2 (0.49) | MKNK2KMT2ASMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL680855 | 0.75 | FGFR1 (0.56) | MKNK2HTTKMT2AALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL4456679 | 0.73 | FGFR1 (0.54) | MKNK2HTTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL467133 | 0.72 | MKNK2 (0.47) | MKNK2HTTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL28839763 | 0.71 | MKNK2 (0.43) | MKNK2KMT2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL28317574 | 0.70 | MKNK2 (0.55) | MKNK2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805951-B1 | Inhibitors of diacylglycerol o-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS INC (US) | 2018-03-14 | — | — | EP | disclosed |